Plant Protein-Derived Antioxidant Peptides: An Overview
Background In recent years, more and more studies have described the antioxidant capacity of plant protein-derived peptides. Plant proteins are considered a new source of antioxidant peptides that can...
View ArticleAnalysis Methods for Peptide-Related Impurities in Peptide Drugs
Background Peptide drugs, as a type of pharmaceutical with molecular weight between small molecule chemical drugs and biopolymers, provide more options for medicinal chemists and have become a hot...
View ArticleClassification of Impurities in Synthetic Peptide Drugs
Advantages of Peptides Peptides are a class of compounds formed by linking multiple amino acids through amide bonds, and their molecular size is between small molecule chemical drugs and...
View ArticleFDA Approved Peptide Drugs in the First Half of 2023
The FDA’s Center for Drug Evaluation and Research (CDER) regulatory approval of a total of 26 NME (New Molecular Entity) drugs in the first half of 2023. It is worth noting that the 26 drugs approved...
View ArticleScreening Strategies for Cyclopeptide Drugs
Cyclopeptides represent one of the most diverse architectures in current drug discovery efforts. Their small size, stability, and ease of synthesis provide an attractive scaffold for targeting and...
View ArticlePeptide Vaccine Design
Vaccines are considered one of the most successful medical interventions in the past few centuries, aiming to harness the human immune system and generate lasting protection against specific diseases....
View ArticleDo Peptide Drugs Need Acylation Blocking at Nα?
The formation of 2,5-diketopiperazine (DKP) with a bicyclic structure is one of the most detrimental side reactions and degradation pathways affecting peptide synthesis. Despite its crucial role as a...
View ArticleCyclic Peptide Synthesis Strategies in Drug Development
Compared to linear peptides, cyclic peptides exhibit excellent biocompatibility and chemical diversity, making them effective in overcoming limitations and playing a crucial role in new drug...
View ArticleComparison of PeptideSynthesis Methods and Techniques
Synthesis of peptides is a complex process that usually involves different synthesis strategies and techniques. The following are some common approaches to peptide synthesis processes and techniques:...
View ArticleDevelopment Progress and Prospects of Antibody-Peptide Conjugates
In the field of weight loss drug development, the recently disclosed clinical data of Amgen’s weight loss candidate drug Maridebart Cafraglutide (referred to as MariTide, formerly known as AMG 133)...
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